SUBSTANCE-P - NEW ASPECTS TO ITS MODULATORY FUNCTION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 39  (4) , 469-477
Abstract
The paper deals with a modulatory function of substance P (SP) with bearing on nociception, behavior, and norepinephrine uptake. The effect of SP on nociception and behavior depended on the original condition of the individuals. The individual response time of mice to thermic stimuli became standardized by SP in the hot-plate test. Disorders in acquisition of avoidance reactions caused by stress were fully normalized by SP, like certain autonomic parameters, such as blood pressure, heart rate, and respiratory rate. SP inhibited or stimulated norepinephrine uptake of hypothalamus preparations depending on the experimental conditions.

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