5-Bromobarbituric Acid : A Mild and Selective Monobrominating Agent Employed in the Synthesis of the Gastrin Antagonist GR174152
- 1 November 1996
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 26 (22) , 4195-4209
- https://doi.org/10.1080/00397919608004658
Abstract
5-Bromobarbituric acid (5) is a convenient reagent for the selective bromination of cyclic imine 3. A facile, in situ synthesis of this reagent involving a disproportionation reaction between barbituric acid and dibromobarbituric acid is described.Keywords
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