Leukomelanoderma Subsequent to the Application of Monobenzyl Ether of Hydroquinone

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Abstract
The role of monobenzyl ether of hydroquinone as a cause of depigmentation has been known since the report of Oliver, Schwartz, and Warren1in 1940. These authors studied 20 patients with a peculiar leukoderma localized to the hands and forearms, produced by a type of rubber gloves in which Agerite Alba had been used as an antioxidant. The leukoderma occurs primarily on the areas in direct contact with the causative agent but was also observed affecting the trunk and extremities. One of their patients was a Negro with a striking depigmentation of the abdomen, upper part of the thighs, and buttocks. The authors stated that this could not be explained except that it was probably due to rubbing sweat and water off his body. Sulzberger2mentioned a Negro with a generalized vitiligoid depigmentation, almost resembling an albino. The discovery of the properties of mono

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