ULTRASTRUCTURAL-STUDY OF ACUTE LYMPHOCYTIC-LEUKEMIA - COMPARISON WITH IMMUNOLOGICAL STUDIES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (2) , 311-322
Abstract
Leukemic cells from 29 cases of acute lymphocytic leukemia (ALL), studied for T [thymus derived] and B [bone marrow derived] cell markers by the use of sheep erythrocyte rosetting and surface immunoglobulin determinations, were examined by EM. The majority of patients (76%) had non-T, non-B neoplasms composed predominantly of relatively small, inactive-appearing cells with frequent nuclear folds. T cell cases (21%) were associated with mediastinal masses and were predominantly composed of large, active-appearing cells with nuclear irregularity and little rough endoplasmic reticulum. One case of B cell origin was not morphologically distinct from the non-T, non-B cell cases.

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