The MexR Repressor of themexAB-oprMMultidrug Efflux Operon inPseudomonas aeruginosa: Characterization of Mutations Compromising Activity

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Abstract
Mutations inmexRyield a multidrug resistance phenotype innalBmutants ofPseudomonas aeruginosaas a result of derepression of themexAB-oprMmultidrug efflux operon. MexR produced by severalnalBstrains carried single amino acid changes that compromised MexR stability or its ability to dimerize. Changes at residues L95 and R21, however, produced a stable MexR protein capable of dimerization and, thus, likely compromised DNA binding.