Histologic evidence for death of cortical neurons after spinal cord transaction
- 1 August 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 34 (8) , 1002
- https://doi.org/10.1212/wnl.34.8.1002
Abstract
Dying cortical neurons, identified by standard histologic criteria, were observed in the rat sensory/motor cortex after spinal cord transection. The peak incidence of these changes was 10 weeks after injury. At that time, spinal-cord-injured animals showed 10 times as many abnormal cells as were found in matched controls (p≤ 0.05). Dying cells were found in the same anatomic location as corticospinal neurons axotomized by the experimental injury, and at the expected time after injury. The survival of corticospinal neurons in these young adult rats may be dependent on obtaining a crucial input from an appropriate target cell (neuron).This publication has 3 references indexed in Scilit:
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- Cytologic Observations on Axotomized Feline Betz CellsJournal of Neuropathology and Experimental Neurology, 1979
- Abnormal ultrastructural appearances in axons of feline pericruciate cortex after lateral funiculotomyActa Neuropathologica, 1978