Photochemotherapy for mycosis fungoides: a clinical and histological study

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Abstract
Patients (9) with stages 2 or 3 mycosis fungoides (MF) and 1 with Sezary''s syndrome were treated with oral methoxsalen and long-wave UV light. Previous therapy had either failed or achieved only partial control. Satisfactory clinical control was achieved in all but 1 case. Histological improvement was seen in all cases, but complete clearance of lymphoid infiltrate was noted mainly in epidermal and papillary dermal infiltrates. Lower dermal infiltrate remained largely unchanged. The case of Sezary''s syndrome was inadequately controlled with systemic prednisone and cyclophosphamide, but addition of photochemotherapy improved the erythema and pruritus. This shows that photochemotherapy may have a place in MF treatment both alone and perhaps in conjunction with other treatments. An early relapse occurred on stopping photochemotherapy in 4 cases, but 1 patient has had 3 mo. full remission.

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