Estimating Recombination Rates From Single-Nucleotide Polymorphisms Using Summary Statistics
- 1 November 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 174 (3) , 1517-1528
- https://doi.org/10.1534/genetics.106.060723
Abstract
We describe a novel method for jointly estimating crossing-over and gene-conversion rates from population genetic data using summary statistics. The performance of our method was tested on simulated data sets and compared with the composite-likelihood method of R. R. Hudson. For several realistic parameter values, the new method performed similarly to the composite-likelihood approach for estimating crossing-over rates and better when estimating gene-conversion rates. We used our method to analyze a human data set recently genotyped by Perlegen Sciences.Keywords
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