Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action.

  • 1 January 1955
    • journal article
    • Vol. 13  (6) , 937-98
Abstract
For morphine-, morphinan-, pethidine-, methadone-, and dithienyl-butenylamine groups of analgesic compounds a systematic survey is given of how analgesic activity is quantitatively affected by alteration of the chemical constitution. Features common to the structural formulae of substances with morphine-like analgesic effect are pointed out.