Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence

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Abstract
Sodium- and potassium-dependent ATPase [(Na+ + K+)ATPase], which is responsible for the active transport of Na+ and K+, is distributed universally among animal cell membranes and consists of two types of subunits, α and β (refs 1–4). The larger α-subunit with a relative molecular mass (Mr) of 84,000–120,000 is thought to have the catalytic role. We have now cloned and sequenced DNA complementary to the Torpedo californica electroplax messenger RNA encoding the α-subunit of (Na+ + K+)ATPase and have deduced the complete ammo-acid sequence of the polypeptide. Some structural features of the α-subunit molecule related to the function of this active-transport protein are discussed.

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