SCHILDER'S DISEASE

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Abstract
Diffuse sclerosis of the brain was first described as a disease entity by Heubner (1897). He regarded it as a disease appearing in childhood and characterized by diffuse destruction of the white matter in one or both hemispheres. Since then, many cases have been described, giving rise to detailed discussion of the character of this condition and its independent existence as a specific disease. In 1912, Schilder1tried to single out and compile from the class of diffuse scleroses of the brain certain cases which he found on personal observation made up an at least anatomically well defined entity. He called it "encephalitis periaxialis diffusa," as he regarded it as an inflammation diffusely destroying the white matter, leaving the axis cylinders comparatively uninjured. According to him, the disease appears in childhood. He found it characterized by: its great extent in focal form, but with the superficial brain structure unaltered,

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