Could dehydration in infancy lead to high blood pressure?
- 1 February 2006
- journal article
- research article
- Published by BMJ in Journal of Epidemiology and Community Health
- Vol. 60 (2) , 142-143
- https://doi.org/10.1136/jech.2005.040006
Abstract
The Avon longitudinal study of parents and children (ALSPAC) is a population based study investigating the health and development of children (http://www.alspac.bris.ac.uk). Women living in three health districts of Bristol, England with expected delivery dates between April 1991 and December 1992 were eligible, 14 541 (85%) enrolled, and there were 14 049 singleton and twin live births. Ethical approval was obtained from the ALSPAC and local research ethics committees. In questionnaires filled out by mothers when the infant was 6 months of age eight cohort members were reported as having been admitted to hospital for dehydration. Of these six attended the 7 year old clinic, where blood pressure was recorded. Comparing these six with the cohort members who attended the clinic and who had not been admitted for dehydration (n = 7834), systolic and diastolic blood pressures were found to be higher (see table 1), although effect estimates were imprecise, were lower for systolic than for diastolic blood pressure, and the confidence intervals for the systolic blood pressure result overlapped the null. This difference was not attenuated by using multiple regression to adjust for potential confounding factors.Keywords
This publication has 8 references indexed in Scilit:
- Early life determinants of adult blood pressureCurrent Opinion in Nephrology and Hypertension, 2005
- An evolutionary explanation of the plasticity of salt preferences: Prophylaxis against sudden dehydrationMedical Hypotheses, 2003
- Relation between number of siblings and adult mortality and stroke risk: 25 year follow up of men in the Collaborative studyJournal of Epidemiology and Community Health, 2003
- Secular trends in mortality by stroke subtype in the 20th century: a retrospective analysisThe Lancet, 2002
- Secular changes in blood pressure in childhood, adolescence and young adulthood: systematic review of trends from 1948 to 1998Journal of Human Hypertension, 2002
- Infant mortality, stomach cancer, stroke, and coronary heart disease: ecological analysisBMJ, 2000
- Long-term Effects of Neonatal Sodium Restriction on Blood PressureHypertension, 1997
- Childhood risk factors for ischaemic heart disease and strokePaediatric and Perinatal Epidemiology, 1990