Histological and serological features of experimental autoimmune thymitis in guinea-pigs.

  • 1 May 1967
    • journal article
    • Vol. 2  (3) , 257-68
Abstract
Guinea-pigs injected with thymus or muscle in complete Freund's adjuvant developed `experimental autoimmune thymitis'. Thymitis was defined by accumulations of lymphocytes around Hassall's corpuscles in the thymic medulla and by distortion and compression of reticulin fibres towards the cortico-medullary junction. Thymitis occurred in five of eight animals injected with thymus and four of four animals injected with muscle.