Increased T-cell receptor Vβ2 chain expression in skin homing lymphocytes in psoriasis
- 24 May 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 140 (5) , 845-848
- https://doi.org/10.1046/j.1365-2133.1999.02813.x
Abstract
Studies have shown over-representation of certain T-cell receptor (TCR) Vβ chains in lesional psoriatic skin, implying selection or expansion, possibly by bacterial superantigen. We investigated the pattern of TCR Vβ chain usage in peripheral blood lymphocytes (PBL) bearing the skin homing receptor cutaneous lymphocyte associated antigen (CLA) in psoriasis patients. Results showed increased expression of TCR Vβ2 in CLA-positive PBL in psoriasis patients (n = 15) compared with normals (n = 10); P < 0.002. As Vβ2 is preferentially expressed by lymphocytes responding to certain bacterial superantigens, this study could possibly indicate a role for superantigens in the pathogenesis of psoriasis.Keywords
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