INFLUENCE OF COBRA VENOM (COF) AND PNEUMOCOCCAL S-III CAPSULAR POLYSACCHARIDE ON IMMUNOLOGICAL HUMORAL RESPONSE AND VISCERAL DISTRIBUTION OF ANTIGENS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 25  (4) , 469-475
Abstract
The immune response to sheep erythrocytes was compared in mice treated with cobra venom (CoF) and with pneumococcal capsular antigen S III. Suppression of the immune response (in both cases) was attributed to the ability of both tested substances to activate the 3rd component of complement. CoF and S III both changed the organ localization of labeled antigens capable of activating complement. No evidence for an alternative pathway by which S III could activate complement was found. CoF and S III were compared in the light of their ability to suppress the immune response.

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