Topical nonsteroidal anti‐inflammatory gel for the prevention of peripheral vein thrombophlebitis

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Abstract
Summary: A double‐blind, randomised, placebo‐controlled study was undertaken to determine whether topical application of a nonsteroidal anti‐inflammatory gel to skin overlying peripheral vein cannula sites has a role in reducing the incidence or delaying the onset of peripheral vein thrombophlebitis. Fifty normal subjects had intravenous cannulae placed in right and left arms. Subjects were randomised to receive twice daily application of either active nonsteroidal anti‐inflammatory gel or placebo gel to each cannula site. Cannula sites were observed and signs and symptoms of inflammation recorded up to 108 h. If any site had signs extending beyond 2 cm then the cannula was removed. Cannula sites that had ‘active’ gel applied had half the incidence of marked signs at 108 h (44% vs 22%, p < 0.05). These results suggest that local application of topical nonsteroidal anti‐inflammatory gel to cannula sites may have a significant role to play in the prevention of peripheral vein thrombophlebitis.