EFFECTS OF HYDROQUINONE, HEMATIN AND HEME-CONTAINING PROTEINS ON PROSTAGLANDIN BIOSYNTHESIS BY METHYLCHOLANTHRENE-TRANSFORMED MOUSE BALB-3T3 FIBROBLASTS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 197  (3) , 567-574
Abstract
Cultured methylcholanthrene-transformed 3T3 mouse fibroblasts secrete large amounts of prostaglandin [PG] into the medium. PG biosynthesis by these cells can be stimulated by arachidonic acid and, to a lesser extent, by glutathione and porphyrin. In the presence of hydroquinone, PG production is increased. The most striking increases are seen at concentrations that are lethal. Porphyrins, when added to cells in the presence of lethal levels of hydroquinone, inhibit stimulation of PGE2 synthesis but stimulate the production of PGF2.alpha.

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