KINETIC STUDIES ON IMMUNE HEMOLYSIS

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Abstract
The combination between sheep erythrocytes and rabbit antibody to these cells is reversible. As a result, molecules of hemolytic antibody which have acted in conjunction with complement in causing hemolysis of the red cells, can dissociate from the site of combination upon the surface of the red cell and can then recombine with another site on the same or another red cell. In this fashion a molecule of hemolytic antibody can act repeatedly in conjunction with complement in a manner similar to that of an enzyme. Hemolytic antisera to sheep erythrocytes prepared in different rabbits may vary in respect to the dissociation tendency, and as a result may exhibit different rates of "transfer" of antibody from cell to cell. These differences are evident from the kinetic behavior of various antisera in the hemolytic reaction.
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