Tensile strengths of paracetamol and Avicel powders and their mixtures

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Abstract
Measurements were made of the tensile strengths of paracetamol and Avicel powders and of their mixtures. Two quantities were derived from the results; m, a universal constant whose value was 1·00 + 0·23 and α, a constant of the material. The value of α for paracetamol was much larger than that for Avicel and increased slightly with increase in particle size. Adding 25% w/w of Avicel to paracetamol produced a significant decrease in α and this fact may account for its use as an excipient in the tableting of paracetamol.