Modulating Effect of Beta-Endorphin, Somatostatin, Substance P and Vasoactive Intestinal Peptide on the Proliferative Response of Peripheral Blood T Lymphocytes of Nickel-Allergic Patients to Nickel Sulfate

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Abstract
The influence of beta-endorphin, somatostatin, substance P (SP) and vasoactive intestinal peptide (VIP) was tested on the proliferative response of peripheral blood T lymphocytes of nickel-allergic subjects to nickel sulfate. With somatostatin, 10––6––10––10M, SP, 10––9 Mand VIP, 10––7–10––8M, added 1 h after nickel sulfate, there was an enhancement of the response, while a slight suppression was obtained with SP, 10––6M. At 3 days after nickel sulfate, beta-endorphin, 10––6––10––12M, somatostatin, 10––7–10––9M and SP, 10––7––10––11M, gave an enhancement of the response.