Effect of Hyaluronic Acid on Phagocytosis of Opsonized Latex Particles

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Abstract
In an in vitro model system using isolated human granulocytes high MW hyaluronic acid stimulated the initial rate of phagocytosis of complement-opsonized latex particles. This specific quality was dependent on the molecular size and occurred at low concentrations (1-10 mg/l) of hyaluronic acid. At high concentrations (> 100 mg/l) hyaluronic acid inhibited the initial rate of phagocytosis of Ig[immunoglobulin]G- and complement-opsonized particles. The latter effect was shared with chondoitin sulfate, heparan sulfate and heparin. Hyaluronic acid may be instrumental in controlling inflammatory processes.