PROTECTIVE VACCINATION OF HORSES WITH MODIFIED EQUINE ENCEPHALOMYELITIS VIRUS

7 June 1935

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 81 (2110) , 572
https://doi.org/10.1126/science.81.2110.572

Abstract

By serial passage through pigeons a strain of equine en-cephalomyelitis virus of the eastern type has been bo changed that it usually failed to produce disease when large amts. of it were injected subcut. into guinea pigs. The majority of the guinea pigs so treated became immune to intracerebral injection with unmodified virus. 4 out of 9 horses injected subcut. with modified virus became immune to intracerebral injection with large amounts of unmodified virus.