The control of liver fat by triethyl-β-hydroxyethylammonium hydroxide

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Abstract
To determine whether the preventive action of choline on liver fat deposition is exercised through lecithin formation, triethyl-[beta]-hydroxyethyl-ammonium hydroxide which has a similar effect on liver fat was used. This compound can be separated from choline because of the lower solubility of its chloroaurate. Control groups of animals received a "fat" or "cholesterol" fatty liver-producing diet while other groups received the same diet with the addition of either choline or triethyl-/3-hydroxyethylammonium hydroxide. The phosphatides were prepared from the livers and the bases obtained by hydrolysis. After removal of cholamine, the chloroaurates were prepared and fractionally crystallized. No evidence was obtained of the presence of triethyl-[beta]-hydroxyethyl-ammonium hydroxide in the livers of the animals receiving this base, even though the liver fat had been markedly decreased.

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