THE ESSENTIAL PARTICIPATION OF AN ENZYME IN THE INHIBITION OF GROWTH OF TUBERCLE BACILLI BY SPERMINE

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Abstract
Spermine inhibits the multiplication of tubercle bacilli in vitro only if another tissue substance is present in the culture medium. This activating substance occurs as a chemical contaminant of the albumin in commercial bovine plasma fraction V ordinarily added to culture media; it is also found in whole bovine and sheep serum and in aqueous extracts of the guinea pig kidney. No detectable spermine activator is contained in whole human, guinea pig, or rabbit serum.

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