Mutations of theBIK gene in human peripheral B-cell lymphomas
- 16 July 2003
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 38 (1) , 91-96
- https://doi.org/10.1002/gcc.10245
Abstract
BIK, a BH (Bcl2 homology domain)3-only protein, is a proapoptotic member of the BCL2 family. We performed single-strand conformational polymorphism and sequencing analysis of the entire coding region of the BIK gene (exons 2-5) in 71 B-cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B-cell lymphomas (DLBCLs)]. Missense BIK gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in 1 of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the BIK gene is a frequent feature of B-cell lymphomasKeywords
This publication has 13 references indexed in Scilit:
- Cell cycle deregulation in B-cell lymphomasBlood, 2003
- BH-3-only BIK Functions at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from MitochondriaJournal of Biological Chemistry, 2002
- Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53Oncogene, 2002
- BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and BakGenes & Development, 2001
- Phosphorylation of the Pro-apoptotic Protein BIKPublished by Elsevier ,2001
- A High Frequency of Sequence Alterations Is Due to Formalin Fixation of Archival SpecimensPublished by Elsevier ,1999
- Mapping of a target region of allelic loss to a 0.5-cm interval on chromosome 22q13 in human colorectal cancerGastroenterology, 1999
- Expression of the Death Gene Bik/Nbk Promotes Sensitivity to Drug-Induced Apoptosis in Corticosteroid-Resistant T-Cell Lymphoma and Prevents Tumor Growth in Severe Combined Immunodeficient MiceBlood, 1999
- Death pathway genes Fas (Apo-1/CD95) and Bik (Nbk) show no mutations in colorectal carcinomasCell Death & Differentiation, 1999
- Functional Dissection of the Pro-apoptotic Protein BikPublished by Elsevier ,1997