A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

This publication has 39 references indexed in Scilit:

• A Reduced Folate Carrier Mutation Produces Substrate-dependent Alterations in Carrier Mobility in Murine Leukemia Cells and Methotrexate Resistance with Conservation of Growth in 5-Formyltetrahydrofolate
  Journal of Biological Chemistry, 1998
• A Single Amino Acid Difference within the Folate Transporter Encoded by the Murine RFC-1 Gene Selectively Alters its Interaction with Folate Analogues
  Published by Elsevier ,1998
• Leading Article: Oncologic, Endocrine & Metabolic: New antimetabolites in preclinical and clinical development
  Expert Opinion on Investigational Drugs, 1996
• Alteration of Mitochondrial Gene Expression and Disruption of Respiratory Function by the Lipophilic Antifolate Pyrimethamine in Mammalian Cells
  Published by Elsevier ,1995
• Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line
  Published by Elsevier ,1995
• Molecular Cloning of the Human Placental Folate Transporter
  Biochemical and Biophysical Research Communications, 1995
• Optimization of the single-strand conformation polymorphism (SSCP) technique for detection of point mutations
  Human Mutation, 1993
• Pharmacokinetics of Leucovorin Metabolites in Human Plasma as a Function of Dose Administrated Orally and Intravenously
  JNCI Journal of the National Cancer Institute, 1991
• Clinical Science Review: Update on Trimetrexate, a Folate Antagonist with Antineoplastic and Antiprotozoal Properties
  Cancer Investigation, 1991
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
  Analytical Biochemistry, 1976