The biosynthesis of phenazines: incorporation of [14C]shikimic acid
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2411-2415
- https://doi.org/10.1039/p19790002411
Abstract
Specific and self-consistent incorporations of [1-14C]-, [6-14C]-, and [1,6,7-14C3]-shikimic acid into iodinin in Brevibacterium iodinum closely define the orientation of the precursor molecule in the phenazine metabolite. [1,6,7-14C3]Shikimic acid gave phenazine-1-carboxylic acid with one fifth of the activity in the carboxy-group, which requires the involvement of two precursor molecules in biosynthesis or incorporation via a symmetrical intermediate derived from only one precursor molecule. Neither [3H]anthranilic acid nor [14C]dihydrohydroxyanthranilic acid was significantly incorporated into iodinin. Decarboxylation of [ring-14C]pyrazinetetracarboxylic acid under various conditions has been studied; with copper chromite, but not with copper–bipyridyl–quinoline, radioactivity (up to 12%) appeared in the liberated carbon dioxide.This publication has 0 references indexed in Scilit: