Benzodiazepine antagonist Ro 15‐1788

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Abstract
In a double‐blind, randomised trial the efficacy and safety of Ro 15‐1788, a new benzodiazepine antagonist, was assessed in forty adults undergoing gastroscopy under diazepam sedation. Criteria of efficacy were the degree of sedation and anterograde amnesia. There was a significantly faster recovery of the patients after the injection of 0.61.0 mg of Ro 15‐1788 than after placebo. Patients were awake shortly after Ro 15‐1788, but remained drowsy or asleep after placebo administration. There were no side effects of note.