Excretion of indomethacin into saliva following intravenous administration to dogs.

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Abstract
Parotid saliva (Pr) and mandibular-sublingual saliva (MS) were collected separately by means of permanent fistulae to investigate the excretion of indomethacin in saliva of dogs receiving a single i.v. dose of 20 mg/kg. Drops of citric acid solution were placed on the tongue to stimulate salivary secretion. The concentrations of indomethacin both in saliva and plasma declined biexponentially with time. There was a good linear relationship between the drug concentration in each saliva and plasma. The Pr and MS levels were 7.4 and 4.4% of the plasma levels, respectively. Indomethacin concentrations in Pr were significantly higher than in MS (P < 0.05). The roles of salivary pH and salivary protein binding were discussed in respect to the mechanism of salivary excretion of the drug.