Angiogenesis in brain tumors
- 21 January 2003
- journal article
- review article
- Published by Wiley in Microscopy Research and Technique
- Vol. 60 (2) , 225-230
- https://doi.org/10.1002/jemt.10260
Abstract
Angiogenesis is a complex process regulated by multiple stimulatory and inhibitory factors that are able to modulate the migration and/or proliferation of microvascular cells with the objective of formation of neovasculature from preexisting vessels. It involves well-coordinated steps including production and release of angiogenic factors, proteolytic degradation of extracellular matrix components to allow formation of capillary sprout, proliferation and directional migration of microvascular cells, and the final composition of new vessels [Senger (1996) Am. J. Pathol. 149:1–7]. Angiogenesis is present in a number of hypoxic and/or ischemic conditions in the central nervous system, in particular in infarctions and infectious processes. Angiogenesis also plays an important role in malignant primary tumors. Glioblastomas, the most malignant gliomas in adults, are among the most angiogenic of all human tumors. This review will examine recent data of the role of angiogenic growth factors in the neoplastic and reactive conditions in the brain. Microsc. Res. Tech. 60:225–230, 2003.Keywords
This publication has 49 references indexed in Scilit:
- Vascular Endothelial Growth Factor, Hepatocyte Growth Factor/Scatter Factor, Basic Fibroblast Growth Factor, and Placenta Growth Factor in Human Meningiomas and Their Relation to Angiogenesis and MalignancyNeurosurgery, 2000
- Role of vascular endothelial growth factor in the regulation of angiogenesisKidney International, 1999
- Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cellsNeuropathology and Applied Neurobiology, 1999
- Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the vasculature of oligodendrogliomasNeuropathology and Applied Neurobiology, 1998
- Brain Edema in Meningiomas Is Associated with Increased Vascular Endothelial Growth Factor ExpressionNeurosurgery, 1997
- Meningiomas: Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in Angiogenesis and Peritumoral EdemaNeurosurgery, 1997
- A Putative Role for Platelet-Derived Growth Factor in Angiogenesis and Neuroprotection After Ischemic Stroke in HumansStroke, 1997
- Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomasJournal of Neurosurgery, 1996
- Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in HumansStroke, 1996
- Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesisJournal of Neurosurgery, 1994