A RANDOMIZED CONTROLLED TRIAL OF A SHORT COURSE OF CEPHALORIDINE IN THE PREVENTION OF INFECTION AFTER ABDOMINAL HYSTERECTOMY

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Abstract
One hundred patients took part in a randomized controlled trial to test the efficacy of three 1 g doses of cephaloridine in preventing infection after abdominal hysterectomy. The first dose was given as an intravenous bolus at the commencement of surgery and the second and third as intramuscular injections 6 and 12 hours later. Given in this way, cephaloridine was found to be very effective in preventing febrile morbidity, abdominal wound infection and urinary tract infection. It was less effective in preventing pelvic wound infection and postoperative colonization of the vagina with Escherichia coli. Our thanks are due to Dr Clive Dash of Glaxo Laboratories Limited for supplying us with so much information about cephaloridine and for his help and encouragement throughout the trial. We are also grateful to all the hospital staff who helped with the trial.

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