Formation of IgE-Binding Factors by Lymphocytes of HIV-Infected Patients

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Abstract
Peripheral blood mononuclear cells of human immunodeficiency virus infected patients were cultured in the presence or absence of 10 μg/ml human IgE, and culture filtrates were fractionated on IgE-Sepha-rose. IgE-binding factors were assessed in the acid eluate fraction from IgE-Sepharose by both rosette inhibition assay and radioimmunoassay. Among 22 cases studied, mononuclear cells from 9 patients formed IgE-binding factors in the absence of IgE, and those of 13 cases formed the factors upon incubation with IgE. The major cell source of IgE-binding factors was T cells. In 2 cases of human immunodeficiency virus infection, Fcε receptors were detected on both Leu-2+ and Leu-3+ T cells.

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