Quantitative Measurement of Optical Parameters in the Breast Using Time-Resolved Spectroscopy Phantom and Preliminary In Vivo Results

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Abstract
RATIONALE AND OBJECTIVES. Although many optical approaches have been investigated to diagnose breast cancers, optical parameters have never been standardized in phantom experiments; thus, the detectabilities in the various approaches could not be compared. The authors measured optical properties of the breast quantitatively using time-resolved reflectance spectroscopy to optimize the optical condition of the phantom. METHODS. A time-correlated single-photon counting method was used to obtain time-response curves of a phantom and human breasts. The optical parameters were analyzed by fitting the curves to the diffusion equation. RESULTS. The parameters could be quantified within approximately 10% error in the finite breast phantom. In vivo preliminary results showed significant individual differences. CONCLUSIONS. The authors were able to measure the optical parameters quantitatively using time-resolved spectroscopy. This optical information will contribute to the investigation of photon migration in the breast.

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