Effect of N-Allyl Normorphine on Excretion of G-14-Labeled Morphine in Mice

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Abstract
Injn. of N-allylnormorphine into mice previously given C-14-labeled morphine (biosynthetic) has been shown to alter significantly the rate at which morphine is excreted. Animals treated with N-allyl normorphine excreted, via the urine, the greater part of the dose of C-14 morphine within 1-2 hrs., while control maxima were not attained until approx. 4-6 hrs. after admn. of morphine. The exact mechanism involved is not at present known; it is postulated that the kidney or posterior pituitary may be the primary site of action with respect to this antagonism of morphine''s anti-diuretic action.

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