Sympatholysis After Neuron-Specific, N-Type, Voltage-Sensitive Calcium Channel Blockade: First Demonstration of N-Channel Function in Humans
- 1 September 1997
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 30 (3) , 400-403
- https://doi.org/10.1097/00005344-199709000-00019
Abstract
SNX-111 is the first neuronal N-type, voltagesensitive calcium channel (VSCC) blocker to enter clinical drug development. Areas of potential therapeutic utility include treatment of nociceptive and neuropathic pain and neuroprotection after ischemic brain injury. The data presented demonstrate that SNX-111 is biologically active in humans and indicate for the first time a neurophysiologic function of N-type VSCCs in humans.Keywords
This publication has 14 references indexed in Scilit:
- A Selective N-Type Ca2+-Channel Blocker Prevents CA1 Injury 24 h following Severe Forebrain Ischemia and Reduces Infarction following Focal IschemiaJournal of Cerebral Blood Flow & Metabolism, 1994
- Calcium channel antagonist peptides define several components of transmitter release in the hippocampusNeuropharmacology, 1994
- Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (ω-conopeptide MVIIC)Brain Research, 1994
- Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociceptionJournal of Neuroscience, 1994
- A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia.Proceedings of the National Academy of Sciences, 1993
- Inhibition of central neurotransmitter release by ?-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channelNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1987
- Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using .omega.-conotoxin from Conus magus venomBiochemistry, 1987
- Ectopic adrenergic sensitivity in damaged peripheral nerve axons in the ratExperimental Neurology, 1981
- THE SUBSTANTIA GELATINOSA OF THE SPINAL CORDBrain, 1980
- Properties of afferent nerve impulses originating from a neuromaNature, 1974