SOME RESEARCHES ON THE RESPIRATION OF THE CORNEA IN ALBINO RATS

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Abstract
The corneae of albino rats were examined histologically following exposure to gases (e.g., N2, CO2) in a closed chamber. The animals were anesthetized and respiration was maintained by direct intra-tracheal introduction of air. O2 is not essential for corneal vitality. Pure CO2 causes the cornea to become rapidly opaque, but 8% CO2 does not affect it. This latter concn. is sufficient to prevent passage of CO2 from the anterior chamber to the air. It therefore appears that opacity of the cornea following CO2 exposure is a direct effect, and considerable doubt is cast on the theory of selective permeability of the cornea for CO2 which assumes that CO2 is only able to pass from the anterior chamber to the air.

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