ELASTOGENESIS AND ELASTINOLYTIC ACTIVITY IN HUMAN BREAST-CANCER

  • 1 January 1977
    • journal article
    • research article
    • Vol. 26  (1) , 48-52
Abstract
Polymeric elastin was isolated and chemically characterized from 34 human breast cancers. A good correlation exists between the histological and biochemical determinations of elastin. Breast cancer elastin resembles other elastins isolated from ligamentum nuchae or aorta. It differs by its lower proline content and its degree of crosslinking as determined by the ratio (Des [desmosine] + IDes[isodesmosine]/4)/Lys [lysine]. Elastinolytic activity (elastase) was found in human breast cancer extracts. This activity increased with the elastin content of the tumors.

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