A locus for complicated hereditary spastic paraplegia maps to chromosome 1q24‐q32
- 26 November 2003
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 54 (6) , 796-803
- https://doi.org/10.1002/ana.10768
Abstract
We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24‐q32, with a peak logarithm of odds score of 3.05. Ann Neurol 2003;54:796–803Keywords
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