Prostate-Specific Antigen: Its Role in Early Detection, Staging, and Monitoring of Prostatic Carcinoma
- 1 January 1989
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Endourology
- Vol. 3 (2) , 227-236
- https://doi.org/10.1089/end.1989.3.227
Abstract
Prostate-specific antigen (PSA) is a significant improvement over prostatic acid phosphatase as a tumor marker. PSA has established utility immunohistochemically to confirm or refute the prostate as the site of origin for an undifferentiated neoplasm. It also is an excellent tool for monitoring patients after definitive therapy. The role of PSA in early detection of prostatic carcinoma and in staging of established neoplasm remains controversial. The salient features of PSA biochemistry and immunohistochemistry, the serum assays, and the relationship of the antigen to prostatic carcinoma and nonmalignant prostatic pathology are reviewed. The use of PSA in conjunction with other detection modalities such as prostatic ultrasound are discussed.Keywords
This publication has 28 references indexed in Scilit:
- Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the ProstateNew England Journal of Medicine, 1987
- Tumour Markers in Prostatic Carcinoma. A Comparison of Prostate‐specific Antigen with Acid PhosphataseBritish Journal of Urology, 1987
- Needle aspiration and core biopsy of prostate cancer: comparative evaluation with biplanar transrectal US guidance.Radiology, 1987
- Human prostate-specific antigen: structural and functional similarity with serine proteases.Proceedings of the National Academy of Sciences, 1986
- A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein.Journal of Clinical Investigation, 1985
- Immunocytochemical Localisation of Prostate‐specific Antigen: Specificity and Application to Clinical PracticeBritish Journal of Urology, 1985
- Immunohistochemical localization of prostate-specific acid phosphatase and prostate-specific antigen in stage A2 adenocarcinoma of the prostate: Prognostic implicationsHuman Pathology, 1984
- Transrectal ultrasonographyUrology, 1984
- Endoscopic ultrasonic evaluation of the prostate using a transrectal probe: prospective evaluation and acoustic characterization.Radiology, 1983
- Immunoperoxidase localization of prostate-specific antigenThe American Journal of Surgical Pathology, 1982