C4 Polymorphism: Use of a Monoclonal Antibody to Distinguish C4A and C4B Locus Products
- 1 November 1984
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 47 (5) , 362-365
- https://doi.org/10.1111/j.1423-0410.1984.tb04140.x
Abstract
A monoclonal antibody reactive against C4B locus products was used in a passive immunoblotting technique to distinguish C4B from C4A electrophoretic variants. The technique is simple and has the advantage of being able to distinguish clearly those C4B variants which may be either difficult to define by conventional hemolytic assay alone or which would normally be designated as C4B products on account of their lack of hemolytic function. Patterns detected by immunoblotting can be compared directly with patterns obtained by immunofixation with anti-C4 from the same gel.This publication has 11 references indexed in Scilit:
- Statement on the Nomenclature of Human C4 AllotypesImmunobiology, 1983
- A molecular basis for the two locus model of human complement component C4Nature, 1982
- COMPLEMENT C4 IS A MARKER FOR ADULT RHEUMATOID ARTHRITISThe Lancet, 1982
- Family studies of complement C4 and HLA in manHuman Genetics, 1981
- Different HLA antigen associations for the functionally active and inactive products of the complement C4F1 alleleHuman Immunology, 1980
- Inherited structural polymorphism of the fourth component of human complement.Proceedings of the National Academy of Sciences, 1980
- Localisation of Chido and Rodgers determinants to the C4d fragment of human C4Nature, 1978
- Two HLA-linked loci controlling the fourth component of human complement.Proceedings of the National Academy of Sciences, 1978
- Chido and Rodgers blood groups are distinct antigenic components of human complement C4Nature, 1978
- A New Antibody Specificity, Anti‐Rga, Reacting with a Red Cell and Serum AntigenVox Sanguinis, 1976