EFFECT OF COBALT ON WORK PERFORMANCE UNDER CONDITIONS OF ANOXIA

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Abstract
Cobaltous ion in small doses induced erythropoietic activity in the spleen and liver and increased erythropoiesis in the bone marrow of normal rats. Significant increases in Hb value were observed. Animals so treated were observed to have an increased work performance under conditions of anoxia. Although cobaltous ion in the dosage employed did not retard the growth of normal rats, some evidence of an untoward effect associated with its adm. was indicated by the steady improvement in work performance which was noted immediately after withdrawal of Co and prior to the fall in Hb values. Enlargement of the spleen, apparently caused by vascular congestion, appeared in rats which were subjected to work performance tests and Co treatment and which were sacrificed 6 wks. after Co withdrawal.

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