Alterations in Norepinephrine and Dopamine Content in Selected Brain Areas of Guinea Pigs Adapted to Simulated High Altitude

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Abstract
The alterations in brain content of norepinephrine (NE) and dopamine (DA) were studied in guinea pigs adapted to simulated high altitude (hypobaric hypoxia) equivalent to 5500 m. The animals were adapted for 46 days over 82 days to a pressure of 375 mm Hg. The animals were then killed and the following brain parts dissected: cerebellum, neocortex, caudate head/basal forebrain, diencephalon/rhinencephalon and brain stem. NE and DA content were analyzed by high pressure liquid chromatography with electrochemical detection by a technique described. There was a significant increase of NE and DA in neocortex; a significant increase of DA but not NE in caudate/basal forebrain and a significant decrease of NE and not DA in diencephalon/rhinencephalon.