ORAL USE OF METHSCOPOLAMINE (PAMINE) BROMIDE IN TREATMENT OF DUODENAL ULCER

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Abstract
"Peptic ulcer is the product of a pathological process as a result of which the gastroduodenal mucosa fails to withstand the digestive action of acid gastric juice."1Treatment is limited by the fact that the primary cause of this process is unknown. Nevertheless, free hydrochloric acid seems to be an essential factor in the pathogenesis of peptic ulcer, and satisfactory therapeutic results can be obtained by neutralizing the acid or suppressing its formation. In the past this has been accomplished by the frequent use of antacids, such as calcium carbonate, which chemically neutralize acid. However, since gastric secretion in man is stimulated predominantly via the vagus nerve, there has been an intensive search for drugs that could inhibit vagal impulses either at the parasympathetic ganglions or at the terminal nerve fibers on the parietal cells. Such compounds have been called antisecretory or anticholinergic drugs. Atropine, which has been in

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