Prophylactic antithrombotic therapy with stanozolol in patients with familial antithrombin III deficiency

Abstract
Three patients with familial antithrombin III deficiency underwent a trial of prophylactic antithrombotic therapy with stanozolol. An increase in plasma fibrinolytic activity and antithrombin III was seen. Acute venous thrombosis occurred in 2 patients; in the 1st patient thrombosis was precipitated by venography but in the 2nd no precipitating factor was found. Stanozolol possibly is not a suitable prophylactic agent in patients with familial antithrombin III deficiency.