Inhibitors of the C2-Symmetric HIV-1 Protease: Nonsymmetric Binding of a Symmetric Cyclic Sulfamide with Ketoxime Groups in the P2/P2‘ Side Chains
- 14 September 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 42 (20) , 4054-4061
- https://doi.org/10.1021/jm991054q
Abstract
Symmetric cyclic sulfamides, substituted in the P2/P2‘ position with functional groups foreseen to bind preferentially to the S2/S2‘ subsites of HIV-1 protease, have been prepared. Despite efforts to promote a symmetric binding, the sulfamides seemed prone to bind nonsymmetrically, as deduced from X-ray crystal structure analysis of one of the most potent inhibitors, possessing ketoxime groups in the P2/P2‘ side chains. Ab initio calculations suggested that the nonsymmetric conformation of the cyclic sulfamide scaffold had lower energy than the corresponding symmetric, cyclic urea-like conformation.Keywords
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