EFFECT OF PORTACAVAL-SHUNT ON PLASMA-LIPIDS AND TISSUE CHOLESTEROL-SYNTHESIS IN DOG

  • 1 January 1976
    • journal article
    • research article
    • Vol. 80  (1) , 54-60
Abstract
Portacaval shunt (PCS) was proposed as a therapy for hyperlipidemia; but, its lipid-lowering mechanism is unknown. PCS was performed on 10 mongrel dogs to measure its effect on plasma lipids and on the cholesterol synthesizing ability of the liver and intestines, the major endogenous cholesterol synthesizing tissues. Plasma was analyzed for total cholesterol (CHOL), triglycerides (TG) and the CHOL content of 3 plasma lipoprotein fractions. Jejunal, ileal and hepatic cholesterol synthetic rates were determined by 14C-acetate incorporation to CHOL in tissue slices obtained at operation before PCS and 44 .+-. 4.1 (SD) days after PCS. Plasma CHOL decreased by 18 .+-. 7 (SE), 34 .+-. 8 (SE) and 57 .+-. 14 (SE) mg/100 ml by 4, 6 and 16 wk after PCS, respectively. TG decreased by 13 .+-. 5 (SE), 27 .+-. 5 (SE) and 30 .+-. 9 (SE) mg/100 ml at corresponding time intervals. P for CHOL and TG changes was < 0.05 level. CHOL content of the 3 plasma lipoprotein fractions decreased correspondingly. Intestinal tissue CHOL synthesis rates changed only slightly. Hepatic synthetic rates increased 30-40%, but no synthetic rate changes were statistically significant at the P < 0.05 level. PCS is associated with decreases in plasma CHOL [42%] and TG [53%] in dogs up to 16 wk following operation. Statistically significant changes in endogenous CHOL synthesis were not demonstrated by this study.

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