An Efficient Synthesis of (±)-3-Amino-2-(4-chlorophenyl)-propylphosphonic Acid (PHACLOFEN)
- 1 June 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (06) , 442-443
- https://doi.org/10.1055/s-1989-27279
Abstract
A three step, highly efficient synthesis of the GABA-B antagonist, Phaclofen, is described, which features a Michael addition of a phosphonate to a ß-nitrostyrene.Keywords
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