Recherches sur la formation et l’élimination des érythrocytes dans la thalassémie minime

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Abstract
The bone marrow and hemoglobim-exchange (relations between formation and destruction of red cells) changes in minimal thalassemia were studied. As in thalassemia minor and major, there exists either an augmentation of the hemoglobin-exchange or an erythroblastosis of the bone marrow but of less intensity. The mitotic index remains within physiological limits, even in cases of inversion of the percentage between prophases and anatelophases. Assuming that minimal thalassemia is a compensated form in which anaemia does not exist, then erythroblastosis is only a secondary phenomenon of compensation for hyperhemolysis, and not the anatomical expression of a primarily faulty development of the bone marrow. On the other hand, the hyperhemolysis is the consequence of a primary disorder in the bone marrow leading to the formation of more fragile erythrocytes.

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