PROPOFOL DECREASES RANDOM AND CHEMOTACTIC STIMULATED LOCOMOTION OF HUMAN NEUTROPHILS IN VITRO
Open Access
- 1 January 1993
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 70 (1) , 99-100
- https://doi.org/10.1093/bja/70.1.99
Abstract
We have studied the influence of clinical concentrations of propofol (2,6-diisopropylphenol), emulsified propofol (Diprivan) and the emulsifier of propofol (Intralipid 10%) on random and chemotactic locomotion of human polymorphonuclear leucocytes in an agarose assay. Random locomotion was decreased (P < 0.001) to a similar extent by the three drugs. Concentrations of propofol 2.5 μg ml−1 and greater, and of Diprivan 3.33 μg ml−1 and greater, also reduced chemotaxis (P < 0.05) against both zymosan-activated human serum (C5a) and N-formyl-methionyl-leucylphenylalanine (FMLP), used as chemoattractants. Intralipid reduced chemotaxis towards C5a but not towards FMLP. We conclude that propofol in clinically relevant concentrations may adversely affect leucocyte locomotion in vitro.Keywords
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