Comparative Effectiveness of Five Newly Synthesized Arsenical Compounds in Treatment of Leukemia in Mice

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Abstract
Five trivalent organic arsenical compounds (with the As not attached to the benzene ring) were compared along with K arsenite for their ability to prolong the lives of Ak mice affected with transmitted lymphoid and myeloid leukemia. The compounds tested were: (1) arsenic-tris-(N4-mercaptoacetyl-Nl-benzoyl sulfanilamide Na); (2) tris-(beta-diethylaminoethylthio) arsine HC1; (3) arsenic-tris-(N4-tartaryl-N1-2-thiazolylsulfanilamide Na); (4) tris (beta-hydroxyethylthio) arsine; (5) tris (beta-carboxy-beta-aminoethylthio) arsine. While all of the treated groups of animals showed a significant difference from the untreated control groups, there was little difference among the treated groups. In only 1 group was compound 5 more effective against lymphoid leukemia, than arsenite.

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